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Key Takeaways GHK-Cu is a copper binding tripeptide, not a hormone It modulates extracellular matrix remodeling Its effects are local rather than endocrine Human evidence supports skin and wound applications Systemic anti aging claims exceed available data Sources Pickart L, Thaler MM

Proteins 71 , 278299 (2008) Zhang, R., Li, H., Lei, Y., Han, S.: Different weak CHO contacts in N-Methylacetamide-water system: molecular dynamics simulations and NMR experimental study

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase